Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | BDKRB1 | P46663 | 5/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 6/20 | 0.37 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.37 |
| ▸ | BRS3 | P32247 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3019 | 0.93 | ADRB3 (0.42) | BDKRB1ADRB3PDCD1CD274SCN1A | |
| SCHEMBL1639 | 0.87 | SLC6A4 (0.48) | SLC6A4SLC6A3BDKRB1PDCD1CD274 | |
| SCHEMBL3036 | 0.84 | SLC6A4 (0.46) | SLC6A4SLC6A3BDKRB1PDCD1CD274 | |
| SCHEMBL2721 | 0.83 | BDKRB1 (0.39) | BDKRB1ADRB3PDCD1CD274SCN1A | |
| SCHEMBL2970 | 0.83 | BDKRB1 (0.39) | BDKRB1ADRB3PDCD1CD274SCN1A | |
| SCHEMBL2126 | 0.78 | SCN1A (0.48) | SLC6A4SLC6A3BDKRB1SCN1ASCN2A | |
| SCHEMBL3020 | 0.77 | SCN1A (0.42) | BDKRB1ADRB3PDCD1CD274SCN1A | |
| SCHEMBL3201 | 0.76 | SCN1A (0.49) | SLC6A4SLC6A3BDKRB1SCN1ASCN2A | |
| SCHEMBL2746 | 0.73 | AGTR1 (0.53) | SLC6A4SLC6A3 | |
| SCHEMBL2301 | 0.73 | SCN1A (0.47) | SLC6A4SLC6A3SCN1ASCN2ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |