Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.38 |
| ▸ | SCN1A | P35498 | 2/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | BDKRB1 | P46663 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | BRS3 | P32247 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3020 | 0.93 | SCN1A (0.42) | PDCD1CD274SCN1ASCN2ASCN3A | |
| SCHEMBL3035 | 0.84 | SLC6A4 (0.47) | SLC6A4SLC6A3PDCD1CD274SCN1A | |
| SCHEMBL2971 | 0.83 | BDKRB1 (0.36) | PDCD1CD274SCN1ASCN2ASCN3A | |
| SCHEMBL2722 | 0.83 | BDKRB1 (0.36) | PDCD1CD274SCN1ASCN2ASCN3A | |
| SCHEMBL2127 | 0.77 | SCN1A (0.50) | SLC6A4SLC6A3L3MBTL1SCN1ASCN2A | |
| SCHEMBL3019 | 0.77 | ADRB3 (0.42) | PDCD1CD274SCN1ASCN2ASCN3A | |
| SCHEMBL3202 | 0.75 | SCN1A (0.51) | SLC6A4SLC6A3L3MBTL1SCN1ASCN2A | |
| SCHEMBL2302 | 0.73 | SCN1A (0.51) | SLC6A4SLC6A3L3MBTL1SCN1ASCN2A | |
| SCHEMBL1639 | 0.73 | SLC6A4 (0.48) | SLC6A4SLC6A3CA12CA7CA9 | |
| SCHEMBL1615 | 0.70 | SCN1A (0.51) | SLC6A4SLC6A3L3MBTL1SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |