Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22075960 | 1.00 | MAPT (0.48) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL22075927 | 0.90 | ALDH1A1 (0.48) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL31372228 | 0.89 | PARP1 (0.45) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL24528787 | 0.88 | MPO (0.50) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL29722743 | 0.88 | MPO (0.50) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL29088763 | 0.88 | HSD17B10 (0.49) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL22075942 | 0.84 | TSHR (0.56) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL30457845 | 0.84 | MAPT (0.52) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL30369541 | 0.84 | TSHR (0.56) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL29040439 | 0.84 | MAPT (0.52) | MAPTTP53ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025034789-A1 | ARYLBENZOISOXAZOLE COMPOUNDS AS IP6K AND IPMK DEGRADERS AND METHODS OF USE THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2025-02-13 | — | — | WO | disclosed |
| WO-2023081452-A1 | SMALL-MOLECULE DEGRADERS OF CDK8 AND CDK19 | UNIVERSITY OF SOUTH CAROLINA (US) | 2023-05-11 | — | — | WO | disclosed |