Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | CCR1 | P32246 | 3/20 | 0.38 |
| ▸ | CCR8 | P51685 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11222044 | 0.75 | HSP90AA1 (0.45) | LMNAPARP1KDM4EL3MBTL1HSP90AA1 | |
| SCHEMBL2693525 | 0.70 | HCAR2 (0.42) | LMNAHCAR2KDM4EIDO1MAPT | |
| SCHEMBL8967704 | 0.70 | CYP3A4 (0.46) | LMNAPARP1HCAR2KDM4EL3MBTL1 | |
| SCHEMBL19233003 | 0.68 | DHFR (0.53) | LMNAPARP1KDM4EL3MBTL1HSP90AA1 | |
| SCHEMBL19048958 | 0.68 | DHFR (0.49) | LMNAKDM4EHSP90AA1IDO1MAPT | |
| SCHEMBL3259039 | 0.67 | ALDH1A1 (0.44) | LMNAPARP1KDM4EL3MBTL1HSP90AA1 | |
| SCHEMBL19020615 | 0.67 | ALDH1A1 (0.44) | LMNAPARP1KDM4EL3MBTL1HSP90AA1 | |
| SCHEMBL2760538 | 0.67 | GPR3 (0.59) | LMNAKDM4EL3MBTL1HSP90AA1NPC1 | |
| SCHEMBL30185055 | 0.66 | L3MBTL1 (0.54) | LMNAKDM4EL3MBTL1HSP90AA1NPC1 | |
| SCHEMBL166826 | 0.66 | L3MBTL1 (0.54) | LMNAKDM4EL3MBTL1HSP90AA1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023055827-A1 | PARATHYROID HORMONE (PTH) RECEPTOR ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2023-04-06 | — | — | WO | disclosed |