Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 4/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 3/20 | 0.33 |
| ▸ | GABRD | O14764 | 3/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.33 |
| ▸ | GABRE | P78334 | 3/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.33 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628038 | 0.83 | — | — | |
| Trifluoroacetic Acid SCHEMBL27845057 | 0.74 | CA2 (0.52) | HRH4HRH3GABRPGABRDGABRA1 | |
| SCHEMBL29029022 | 0.73 | PARP1 (0.40) | PARP1PDE2AABL1RIN1SLC2A1 | |
| Trifluoroacetic Acid SCHEMBL30557181 | 0.70 | ACVR1 (0.45) | ABL1KDR | |
| Trifluoroacetic Acid SCHEMBL30967251 | 0.68 | HRH4 (0.43) | HRH4HRH3GABRA1GABRA5GABRB2 | |
| Trifluoroacetic Acid SCHEMBL4627267 | 0.68 | HRH4 (0.43) | HRH4HRH3GABRA1GABRA5GABRB2 | |
| Trifluoroacetic Acid SCHEMBL27685394 | 0.68 | GABRP (0.52) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| 2-Aminopurine SCHEMBL27794196 | 0.68 | HRH4 (0.38) | HRH4HRH3GDAKDM4EALDH1A1 | |
| Adenine SCHEMBL9952923 | 0.67 | MTAP (0.39) | HRH4HRH3PARP1GDAALDH1A1 | |
| Adenine SCHEMBL28086748 | 0.67 | MTAP (0.39) | HRH4HRH3PARP1GDAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12558357-B2 | Tetrahydroquinazoline derivatives as selective cytotoxic agents | MERCK SHARP & DOHME LLC (US) | 2026-02-24 | — | — | US | claimed |
| US-11648250-B2 | Tetrahydroquinazoline derivatives as selective cytotoxic agents | MERCK SHARP & DOHME LLC (US) | 2023-05-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11648250-B2 | Tetrahydroquinazoline derivatives as selective cytotoxic agents | ACIN1, REV1, NFATC1 | HRH4 3871/4885HRH3 3444/4885PARP1 201/4885 |
| US-12558357-B2 | Tetrahydroquinazoline derivatives as selective cytotoxic agents | ACIN1, CD4, CCR8 | HRH4 1244/4885HRH3 1447/4885PARP1 388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.