Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.49 |
| ▸ | HTR3B | O95264 | 2/20 | 0.49 |
| ▸ | HTR3A | P46098 | 2/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26633119 | 1.00 | NOTUM (0.50) | NOTUMHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL22964535 | 0.83 | ADRA2C (0.50) | ALDH1A1MAPTALOX15 | |
| SCHEMBL28436985 | 0.82 | DRD2 (0.46) | HTR7 | |
| SCHEMBL29914669 | 0.82 | DRD2 (0.46) | HTR7 | |
| SCHEMBL27865440 | 0.82 | DRD2 (0.46) | HTR7 | |
| SCHEMBL2722663 | 0.81 | HTR3E (0.50) | NOTUMHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL2722659 | 0.81 | HTR3E (0.50) | NOTUMHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL10182584 | 0.81 | HTR3E (0.50) | NOTUMHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27885782 | 0.81 | ADRB1 (0.51) | CYP1A2ADRB1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL24681252 | 0.80 | LMNA (0.52) | NOTUMCYP3A4HTR1ALMNAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116171276-A | 3- ((1H-pyrazol-4-yl) methyl) -6'- (phenyl) -2H- [1,2' -bipyridin ] -2-one derivatives and related compounds as GRP139 antagonists in methods of treating E.G. depression | 武田药品工业株式会社 | 2023-05-26 | — | — | CN | disclosed |