Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30408109 | 0.83 | HDAC8 (0.52) | CTSSCTSKMAPTKMT2ACTSL | |
| SCHEMBL4927381 | 0.78 | KLK5 (0.49) | CTSSCTSKCTSLACEKLK5 | |
| SCHEMBL661640 | 0.77 | RAB9A (0.56) | ALDH1A1MAPTPOLBMEN1KMT2A | |
| SCHEMBL11562606 | 0.77 | CA12 (0.47) | CTSSCTSKMAPTSCN9ACTSL | |
| SCHEMBL25590241 | 0.76 | CTSL (0.52) | CTSSCTSKALDH1A1MAPTCTSL | |
| SCHEMBL25590242 | 0.75 | CTSL (0.51) | CTSSCTSKALDH1A1MAPTPOLB | |
| SCHEMBL2617135 | 0.75 | PPARA (0.50) | CTSSCTSKCTSLACEKLK5 | |
| SCHEMBL30485006 | 0.74 | CTSK (0.41) | CTSSCTSKMAPTSCN9ATP53 | |
| SCHEMBL28524201 | 0.74 | CTSS (0.47) | CTSSCTSKALDH1A1MAPTSCN9A | |
| SCHEMBL1688823 | 0.73 | CYP1A2 (0.43) | CTSSCTSKCTSLACEKLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250034112-A1 | IMPROVED SELECTIVE JAK2 INHIBITORS AND METHODS OF USE | UNIV YALE (US) | 2025-01-30 | — | — | US | disclosed |
| WO-2023064458-A1 | SELECTIVE JAK2 INHIBITORS AND METHODS OF USE | YALE UNIVERSITY (US) | 2023-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250034112-A1 | IMPROVED SELECTIVE JAK2 INHIBITORS AND METHODS OF USE | JAK2, JAK1, MCL1 | CTSS 4376/4885CTSK 3614/4885ALDH1A1 3859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.