Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 8/20 | 0.53 |
| ▸ | MGLL | Q99685 | 8/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30898354 | 1.00 | ABHD6 (0.53) | ABHD6MGLLFAAHGPR119LIPE | |
| SCHEMBL1810911 | 0.84 | GPR119 (0.50) | MGLLGPR119LIPENOTUMPIM1 | |
| SCHEMBL29427036 | 0.80 | MGLL (0.47) | ABHD6MGLLFAAHGPR119LIPE | |
| SCHEMBL30503545 | 0.80 | MGLL (0.47) | ABHD6MGLLFAAHGPR119LIPE | |
| SCHEMBL29427132 | 0.80 | MGLL (0.47) | ABHD6MGLLFAAHGPR119LIPE | |
| SCHEMBL26631491 | 0.80 | MGLL (0.47) | ABHD6MGLLFAAHGPR119LIPE | |
| SCHEMBL30898351 | 0.79 | ABHD6 (0.48) | ABHD6MGLLGPR119LIPE | |
| SCHEMBL30410188 | 0.79 | ABHD6 (0.48) | ABHD6MGLLGPR119LIPE | |
| SCHEMBL25899063 | 0.76 | GPR119 (0.45) | MGLLGPR119LIPENOTUMPIM1 | |
| SCHEMBL25292247 | 0.76 | MGLL (0.45) | ABHD6MGLLGPR119LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469446-A1 | NEW HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2024-12-04 | — | — | EP | disclosed |
| EP-4416154-A1 | HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023144160-A1 | NEW HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023062049-A1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-04-20 | — | — | WO | disclosed |