Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 3/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | LGMN | Q99538 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL30427064 | 0.83 | MAOA (0.50) | KDM4EMAOAMAOBMKNK1MKNK2 | |
| SCHEMBL28201512 | 0.77 | MAOA (0.54) | KDM4EMAOAMAOBMKNK1MKNK2 | |
| Hydrochloric Acid SCHEMBL28856319 | 0.76 | MAOA (0.53) | KDM4EMAOAMAOBMKNK1MKNK2 | |
| SCHEMBL30334012 | 0.73 | KDM4E (0.45) | KDM4EMAPK1MAOAMAOBNOTUM | |
| SCHEMBL12073303 | 0.70 | MAP2K4 (0.54) | MAPK1 | |
| SCHEMBL22926317 | 0.69 | KDM4E (0.41) | KDM4EMAOAMAOB | |
| SCHEMBL16595983 | 0.69 | MAOA (0.46) | KDM4EMAPK1MAOAMAOBKDM1A | |
| SCHEMBL9989118 | 0.68 | KDM4E (0.57) | KDM4EMAOAMAOBMKNK1MKNK2 | |
| SCHEMBL1144800 | 0.67 | MAOA (0.56) | KDM4EMAOAMAOBNOTUM | |
| SCHEMBL28591105 | 0.67 | MAOA (0.59) | KDM4EMAOAMAOBKDM1ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4441042-A1 | 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME | Rgenta Therapeutics, Inc. (US) | 2024-10-09 | — | — | EP | disclosed |
| WO-2023102231-A1 | 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME | RGENTA THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | WO | disclosed |