SCHEMBL30426693

SCHEMBL30426693

CCOC(=O)[C@H](C)OC(=O)/C(C#N)=C/c1cn(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncccc12

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.46
▸ LMNA P02545 1/20 0.46
▸ APP P05067 4/20 0.45
▸ SNCA P37840 4/20 0.45
▸ KDM4E B2RXH2 3/20 0.43
▸ THRB P10828 2/20 0.43
▸ ENPP2 Q13822 1/20 0.42
▸ ATM Q13315 1/20 0.40
▸ MAPT P10636 3/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ SLC16A1 P53985 4/20 0.38
▸ TP53 P04637 1/20 0.36
▸ RXFP1 Q9HBX9 1/20 0.36
▸ ABCB1 P08183 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29395523 0.91 APP (0.49) ALDH1A1LMNAAPPSNCAKDM4E
SCHEMBL20615236 0.91 APP (0.49) ALDH1A1LMNAAPPSNCAKDM4E
SCHEMBL30426623 0.91 ALDH1A1 (0.56) ALDH1A1LMNAAPPSNCAKDM4E
SCHEMBL30426773 0.88 ALDH1A1 (0.47) ALDH1A1LMNAAPPSNCAKDM4E
SCHEMBL26552311 0.88 APP (0.47) ALDH1A1LMNAAPPSNCAKDM4E
SCHEMBL30426622 0.88 ALDH1A1 (0.58) ALDH1A1LMNAAPPSNCAKDM4E
SCHEMBL30427271 0.87 APP (0.48) ALDH1A1LMNAAPPSNCAKDM4E
SCHEMBL30427343 0.87 APP (0.47) ALDH1A1LMNAAPPSNCAKDM4E
SCHEMBL30426119 0.86 APP (0.55) ALDH1A1LMNAAPPSNCAENPP2
SCHEMBL30426569 0.86 APP (0.47) ALDH1A1LMNAAPPSNCAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240327400-A1 COMPOSITIONS AND METHODS FOR MODULATING HAIR GROWTH THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2024-10-03 — — US disclosed
EP-4172158-A1 COMPOSITIONS AND METHODS FOR MODULATING HAIR GROWTH The Regents of the University of California (US) 2023-05-03 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240327400-A1 COMPOSITIONS AND METHODS FOR MODULATING HAIR GROWTH PC, FH, PDK1 ALDH1A1 614/4885LMNA 3624/4885APP 2860/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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