⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6136319 | 0.74 | — | — | |
| SCHEMBL9716210 | 0.74 | PTGS2 (0.41) | — | |
| SCHEMBL11730335 | 0.73 | LMNA (0.43) | — | |
| SCHEMBL4992062 | 0.70 | — | — | |
| SCHEMBL6136492 | 0.70 | — | — | |
| SCHEMBL11323882 | 0.70 | — | — | |
| SCHEMBL2213459 | 0.70 | — | — | |
| SCHEMBL9455864 | 0.70 | — | — | |
| SCHEMBL1008408 | 0.70 | — | — | |
| SCHEMBL20278472 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 183 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108164461-B | Total synthesis of natural product (+/-) -ylacrine and resolution method of enantiomer | 中国科学院新疆理化技术研究所 | 2021-03-09 | — | — | CN | claimed |
| CN-107129462-B | Total synthesis of natural product (+/-) -achillea base G and resolution method of enantiomer | 中国科学院新疆理化技术研究所 | 2020-04-10 | — | — | CN | claimed |
| CN-106045902-A | Preparation method of 3-bromo-6-methyl-2-pyridylaldehyde | 苏州健雄职业技术学院 | 2016-10-26 | — | — | CN | claimed |
| EP-2196468-B1 | Exo-and diastereo-selective syntheses of himbacine analogs | MERCK SHARP & DOHME (US) | 2013-04-10 | — | — | EP | claimed |
| US-20120296093-A1 | EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS | TOPROL ACQUISITION LLC | 2012-11-22 | — | — | US | claimed |
| US-20110251392-A1 | EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS | TOPROL ACQUISITION LLC | 2011-10-13 | — | — | US | claimed |
| JP-4681616-B2 | — | — | 2011-05-11 | — | — | JP | claimed |
| EP-2196468-A1 | Exo-and diastereo-selective syntheses of himbacine analogs | SCHERING CORPORATION (US) | 2010-06-16 | — | — | EP | claimed |
| US-20090281321-A1 | EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS | SCHERING CORPORATION | 2009-11-12 | — | — | US | claimed |
| EP-1848705-A2 | EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS | SCHERING CORPORATION (US) | 2007-10-31 | — | — | EP | claimed |
| US-20060247450-A1 | Exo- and diastereo- selective syntheses of himbacine analogs | SCHERING CORPORATION | 2006-11-02 | — | — | US | claimed |
| WO-2006076415-A2 | EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS | SCHERING CORPORATION (US) | 2006-07-20 | — | — | WO | claimed |
| US-20250282782-A1 | PYRAZOLOPYRAZINE COMPOUNDS AS SHP2 INHIBITORS | GENZYME CORP (US) | 2025-09-11 | — | — | US | disclosed |
| US-20250034162-A1 | IMIDAZOPYRIMIDINES AS EED INHIBITORS AND THE USE THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2025-01-30 | — | — | US | disclosed |
| CN-119212994-A | Pyrazolopyrazine compounds as SHP2 inhibitors | 建新公司 | 2024-12-27 | — | — | CN | disclosed |
| US-12145944-B2 | Imidazopyrimidines as EED inhibitors and the use thereof | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-11-19 | — | — | US | disclosed |
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |
| US-5250527-A | Enzyme inhibitors; administering to reduce gastric acid secretion | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-10-05 | — | — | US | disclosed |
| EP-0184322-A1 | Benzimidazoles | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-06-11 | — | — | EP | disclosed |
| CN-85108133-A | Compounds process for production thereof | — | 1986-04-10 | — | — | CN | disclosed |