Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 2/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | STAMBP | O95630 | 1/20 | 0.40 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 5/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22387737 | 0.84 | HDAC6 (0.57) | HDAC6HDAC2HDAC1HDAC3 | |
| SCHEMBL24925816 | 0.82 | KDM4E (0.42) | HDAC6HDAC2HDAC1HTTHDAC3 | |
| SCHEMBL198067 | 0.81 | ALDH1A1 (0.52) | HPGD | |
| SCHEMBL26153238 | 0.79 | PRKAB2 (0.43) | HDAC6HDAC2HPGDSHDAC1HTT | |
| SCHEMBL8528960 | 0.79 | HCAR3 (0.36) | HPGDHTTSMN1; SMN2 | |
| SCHEMBL13119220 | 0.77 | KCNJ1 (0.36) | BAZ2BHPGDSMN1; SMN2 | |
| SCHEMBL19300252 | 0.77 | BAZ2B (0.49) | BAZ2BHDAC6HDAC2HDAC8GRM5 | |
| SCHEMBL1435071 | 0.76 | MAPK1 (0.52) | PSMD14TSHR | |
| SCHEMBL12017909 | 0.76 | BAZ2B (0.53) | BAZ2BHDAC6HDAC2HDAC8GRM5 | |
| SCHEMBL24065698 | 0.75 | HCAR3 (0.34) | HDAC6HDAC2HDAC8HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405344-A2 | PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS | Xenon Pharmaceuticals Inc. (CA) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049369-A2 | PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS | XENON PHARMACEUTICALS INC. (CA) | 2023-03-30 | — | — | WO | disclosed |