Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CHRND | Q07001 | 5/20 | 0.46 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.46 |
| ▸ | CHRNG | P07510 | 1/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21466071 | 0.97 | ALDH1A1 (0.50) | MDM4MDM2ALDH1A1GRIA1NPSR1 | |
| SCHEMBL29352083 | 0.97 | ALDH1A1 (0.50) | MDM4MDM2ALDH1A1GRIA1NPSR1 | |
| SCHEMBL3929918 | 0.95 | ALDH1A1 (0.57) | MDM4MDM2ALDH1A1GRIA1BACE1 | |
| SCHEMBL12009639 | 0.95 | ALDH1A1 (0.57) | MDM4MDM2ALDH1A1GRIA1BACE1 | |
| SCHEMBL29349987 | 0.91 | ALDH1A1 (0.46) | MDM4MDM2ALDH1A1GRIA1NPSR1 | |
| SCHEMBL14049475 | 0.88 | ALDH1A1 (0.44) | MDM4MDM2ALDH1A1GRIA1NPSR1 | |
| SCHEMBL23169896 | 0.88 | ALDH1A1 (0.62) | ALDH1A1POLBTP53 | |
| SCHEMBL3935791 | 0.88 | OPRM1 (0.55) | MDM4MDM2ALDH1A1BACE1TP53 | |
| SCHEMBL21884113 | 0.88 | ALDH1A1 (0.46) | MDM4MDM2ALDH1A1NPSR1BACE1 | |
| SCHEMBL23864850 | 0.88 | ALDH1A1 (0.47) | MDM4MDM2ALDH1A1NPSR1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025235984-A1 | MILLIMETER-SCALE BIORESORBABLE PACEMAKER WITH OPTOELECTRONIC SYSTEM AND POWERING SYSTEM AND APPLICATIONS THEREOF | NORTHWESTERN UNIVERSITY (US) | 2025-11-13 | — | — | WO | claimed |
| US-20260098847-A1 | TEXTURED FILM FOR USE IN A DISSOLUTION ADAPTER AND USES THEREOF | UNIV CONNECTICUT (US) | 2026-04-09 | — | — | US | disclosed |
| US-12569675-B2 | Electrode apparatus for tissue stimulation and related method of use | AXOGEN CORPORATION (US) | 2026-03-10 | — | — | US | disclosed |
| WO-2025235984-A1 | MILLIMETER-SCALE BIORESORBABLE PACEMAKER WITH OPTOELECTRONIC SYSTEM AND POWERING SYSTEM AND APPLICATIONS THEREOF | NORTHWESTERN UNIVERSITY (US) | 2025-11-13 | — | — | WO | disclosed |
| EP-4456967-B1 | ELECTRODE APPARATUS FOR TISSUE STIMULATION | AXOGEN CORP (US) | 2025-08-27 | — | — | EP | disclosed |
| EP-4456967-A1 | ELECTRODE APPARATUS FOR TISSUE STIMULATION | Axogen Corporation (US) | 2024-11-06 | — | — | EP | disclosed |
| WO-2023129271-A1 | ELECTRODE APPARATUS FOR TISSUE STIMULATION | AXOGEN CORPORATION (US) | 2023-07-06 | — | — | WO | disclosed |
| US-20230201577-A1 | ELECTRODE APPARATUS FOR TISSUE STIMULATION AND RELATED METHOD OF USE | AXOGEN CORPORATION (US) | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260098847-A1 | TEXTURED FILM FOR USE IN A DISSOLUTION ADAPTER AND USES THEREOF | PGRMC2, TNFSF11, PGRMC1 | MDM4 2721/4885MDM2 2415/4885ALDH1A1 2595/4885 |
| US-12569675-B2 | Electrode apparatus for tissue stimulation and related method of use | CD69, ICOS, PIEZO1 | MDM4 4784/4885MDM2 4596/4885ALDH1A1 3285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.