Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 14/20 | 0.51 |
| ▸ | MAOB | P27338 | 10/20 | 0.51 |
| ▸ | MAOA | P21397 | 12/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3422301 | 0.85 | HTR2C (0.61) | KDM1AMAOBMAOAHTR2CHTR2A | |
| SCHEMBL3419759 | 0.85 | HTR2C (0.61) | KDM1AMAOBMAOAHTR2CHTR2A | |
| SCHEMBL3031647 | 0.85 | HTR2C (0.61) | KDM1AMAOBMAOAHTR2CHTR2A | |
| SCHEMBL6998583 | 0.85 | HTR2C (0.61) | KDM1AMAOBMAOAHTR2CHTR2A | |
| (+)-Tranylcypromine SCHEMBL15541916 | 0.84 | MAOB (0.67) | KDM1AMAOBMAOAHTR2CKDM4E | |
| Trifluoroacetic Acid SCHEMBL15541698 | 0.84 | SLC9A1 (0.50) | KDM1AMAOBMAOAHTR2CHTR2A | |
| Trifluoroacetic Acid SCHEMBL15541699 | 0.84 | SLC9A1 (0.50) | KDM1AMAOBMAOAHTR2CHTR2A | |
| Trifluoroacetic Acid SCHEMBL15540595 | 0.79 | KDM1A (0.54) | KDM1AHTR2CHTR2AHTR2BKCNH2 | |
| Trifluoroacetic Acid SCHEMBL30423767 | 0.76 | SLC9A1 (0.46) | KDM1AMAOBMAOAHTR2CHTR2A | |
| Trifluoroacetic Acid SCHEMBL27838178 | 0.75 | KDM1A (0.40) | KDM1AHTR2CHTR2AHTR2BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299100-B2 | Potent and selective neuronal nitric oxide synthase inhibitors with improved membrane permeability | NORTHWESTERN UNIVERSITY (US) | 2012-10-30 | — | — | US | disclosed |
| US-20100190230-A1 | Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors with Improved Membrane Permeability | NORTHWESTERN UNIVERSITY | 2010-07-29 | — | — | US | disclosed |
| WO-2010085749-A2 | POTENT AND SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS WITH IMPROVED MEMBRANE PERMEABILITY | NORTHWESTERN UNIVERSITY (US) | 2010-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190230-A1 | Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors with Improved Membrane Permeability | NOS1, NOS2, NOS3 | KDM1A 2593/4885MAOB 95/4885MAOA 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.