SCHEMBL3045378

SCHEMBL3045378

Fc1ccc(Cc2ccc(N3CCNCC3)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 4/20 0.52
HTR3E A5X5Y0 3/20 0.52
HTR3B O95264 3/20 0.52
HTR3A P46098 3/20 0.52
HTR3D Q70Z44 3/20 0.52
HTR3C Q8WXA8 3/20 0.52
SIGMAR1 Q99720 3/20 0.52
HTR1A P08908 2/20 0.51
HTR7 P34969 2/20 0.51
POLB P06746 1/20 0.51
MAOB P27338 1/20 0.51
CETP P11597 1/20 0.51
MAPT P10636 3/20 0.49
KDM4E B2RXH2 1/20 0.47
TP53 P04637 1/20 0.47
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47
MAPK1 P28482 1/20 0.47
HTT P42858 1/20 0.47
GFER P55789 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL233425 0.89 ADRB1 (0.63) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL894537 0.89 ADRB1 (0.63) ADRB1HTR3EHTR3BHTR3AHTR3D
Piperazine SCHEMBL7486912 0.87 ADRB1 (0.61) ADRB1HTR3EHTR3BHTR3AHTR3D
Hydrochloric Acid SCHEMBL714521 0.87 ADRB1 (0.61) ADRB1HTR3EHTR3BHTR3AHTR3D
Hydrochloric Acid SCHEMBL1005870 0.87 ADRB1 (0.61) ADRB1HTR3EHTR3BHTR3AHTR3D
Bromide SCHEMBL10674981 0.87 ADRB1 (0.61) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL14724611 0.85 HTR7 (0.59) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL6560078 0.84 SIGMAR1 (0.68) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL943026 0.83 HTR7 (0.70) ADRB1HTR3EHTR3BHTR3AHTR3D
Hydrochloric Acid SCHEMBL2881381 0.82 SIGMAR1 (0.66) ADRB1HTR3EHTR3BHTR3AHTR3D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200253958-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE SRX CARDIO, LLC 2020-08-13 US claimed
US-11925637-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use SRX CARDIO, LLC (US) 2024-03-12 US disclosed
US-20220047582-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE SRX CARDIO, LLC 2022-02-17 US disclosed
US-20220047582-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE SRX CARDIO, LLC 2022-02-17 US disclosed
US-10980801-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use SRX CARDIO, LLC (US) 2021-04-20 US disclosed
US-10980801-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use SRX CARDIO, LLC (US) 2021-04-20 US disclosed
US-20200253958-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE SRX CARDIO, LLC 2020-08-13 US disclosed
US-20200253958-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE SRX CARDIO, LLC 2020-08-13 US disclosed
US-10568882-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use SRX CARDIO, LLC (US) 2020-02-25 US disclosed
US-10568882-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use SRX CARDIO, LLC (US) 2020-02-25 US disclosed
US-6469010-B1 COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD SUNTORY LIMITED (JP) 2002-10-22 US disclosed
US-6407099-B1 SUPPRESSING CYTOTOXIC CALCIUM OVERLOAD AND LIPID PEROXIDATION; ANTIEPILEPTIC, ANTIISCHEMIC, AND ANTIEDEMIC AGENTS; BRAIN, NERVOUS SYSTEM, AND CARDIOVASCULAR DISORDERS SUNTORY LIMITED (JP) 2002-06-18 US disclosed
EP-0757986-B1 Arylpiperidine and arylpiperazine derivatives and drugs containing the same SUNTORY LTD (JP) 2002-06-12 EP disclosed
EP-1138678-A2 Process for making N-((4-phenyl) methylphenyl) piperazines SUNTORY LIMITED (JP) 2001-10-04 EP disclosed
US-6048876-A ANTICONVULSANTS; ANTIEPILEPIC AGENT SUNTORY LIMITED (JP) 2000-04-11 US disclosed
EP-0958280-A1 ARYLPIPERIDINOPROPANOL AND ARYLPIPERAZINOPROPANOL DERIVATIVES AND PHARMACEUTICALS CONTAINING THE SAME SUNTORY LIMITED (JP) 1999-11-24 EP disclosed
WO-1999023072-A1 ARYLPIPERIDINOPROPANOL AND ARYLPIPERAZINOPROPANOL DERIVATIVES AND PHARMACEUTICALS CONTAINING THE SAME SUNTORY LIMITED (JP) 1999-05-14 WO disclosed
US-5723475-A Arylpiperidine and arylpiperazine derivatives and medicament containing the same SUNTORY LIMITED (JP) 1998-03-03 US disclosed
EP-0757986-A1 ARYLPIPERIDINE AND ARYLPIPERAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME SUNTORY LIMITED (JP) 1997-02-12 EP disclosed
EP-0755923-A1 AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR SUNTORY LIMITED (JP) 1997-01-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200253958-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE PCSK9, LDLR, PCSK7 ADRB1 1401/4885HTR3E 1341/4885HTR3B 1605/4885
US-20220047582-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE PCSK9, LDLR, PCSK7 ADRB1 1401/4885HTR3E 1341/4885HTR3B 1605/4885
US-10980801-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use PCSK9, LDLR, PCSK7 ADRB1 1401/4885HTR3E 1341/4885HTR3B 1605/4885
US-11925637-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use PCSK9, LDLR, PCSK7 ADRB1 1401/4885HTR3E 1341/4885HTR3B 1605/4885
US-10568882-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use PCSK9, LDLR, PCSK7 ADRB1 1401/4885HTR3E 1341/4885HTR3B 1605/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.