SCHEMBL6560078

SCHEMBL6560078

c1ccc(Cc2ccc(N3CCNCC3)cc2)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 5/20 0.68
ADRB1 P08588 4/20 0.68
HTR3E A5X5Y0 4/20 0.68
HTR3B O95264 4/20 0.68
HTR3A P46098 4/20 0.68
HTR3D Q70Z44 4/20 0.68
HTR3C Q8WXA8 4/20 0.68
TAAR1 Q96RJ0 1/20 0.61
CETP P11597 2/20 0.59
LTA4H P09960 2/20 0.59
HTR6 P50406 3/20 0.56
USP2 O75604 2/20 0.56
ALDH1A1 P00352 1/20 0.56
TSHR P16473 1/20 0.56
HSD17B10 Q99714 1/20 0.56
HTR5A P47898 1/20 0.51
HTR1A P08908 2/20 0.50
HTR7 P34969 1/20 0.50
ADRB2 P07550 1/20 0.48
NCF1 P14598 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2881381 0.98 SIGMAR1 (0.66) SIGMAR1ADRB1HTR3EHTR3BHTR3A
SCHEMBL588594 0.84 ADRB1 (0.79) SIGMAR1ADRB1HTR3EHTR3BHTR3A
SCHEMBL3045378 0.84 ADRB1 (0.52) SIGMAR1ADRB1HTR3EHTR3BHTR3A
SCHEMBL5301158 0.82 CHKA (0.58) LTA4HALDH1A1TSHRHSD17B10
Phenylpiperazine SCHEMBL55125 0.82 ADRB1 (1.00) SIGMAR1ADRB1HTR3EHTR3BHTR3A
Phenylpiperazine SCHEMBL27858598 0.82 ADRB1 (1.00) SIGMAR1ADRB1HTR3EHTR3BHTR3A
Phenylpiperazine SCHEMBL24889 0.82 ADRB1 (1.00) SIGMAR1ADRB1HTR3EHTR3BHTR3A
Phenylpiperazine SCHEMBL29135595 0.82 ADRB1 (1.00) SIGMAR1ADRB1HTR3EHTR3BHTR3A
SCHEMBL28198974 0.81 CHKA (0.56) LTA4HALDH1A1TSHRHSD17B10
SCHEMBL5573099 0.81 DRD4 (0.74) SIGMAR1ADRB1HTR3EHTR3BHTR3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11925637-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use SRX CARDIO, LLC (US) 2024-03-12 US claimed
US-20220047582-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE SRX CARDIO, LLC 2022-02-17 US claimed
US-10980801-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use SRX CARDIO, LLC (US) 2021-04-20 US claimed
US-20200253958-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE SRX CARDIO, LLC 2020-08-13 US claimed
CN-110156752-A 2- [(pyridine -2- ylmethyl) sulfenyl] -1H- benzimidazoles compound and application 沈阳药科大学 2019-08-23 CN claimed
CN-110003176-A Benzimidazoles compound and its application containing amide 沈阳药科大学 2019-07-12 CN claimed
EP-0675118-B1 Biphenylderivatives, process for their preparation and their use as medicaments EISAI CO LTD (JP) 2002-10-09 EP claimed
US-11925637-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use SRX CARDIO, LLC (US) 2024-03-12 US disclosed
US-20220047582-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE SRX CARDIO, LLC 2022-02-17 US disclosed
US-20220047582-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE SRX CARDIO, LLC 2022-02-17 US disclosed
US-10980801-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use SRX CARDIO, LLC (US) 2021-04-20 US disclosed
US-10980801-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use SRX CARDIO, LLC (US) 2021-04-20 US disclosed
US-20200253958-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE SRX CARDIO, LLC 2020-08-13 US disclosed
US-7750012-B2 Biaryl nitrogen-heterocycle inhibitors of LTA4H for treating inflammation DECODE GENETICS EHF (IS) 2010-07-06 US disclosed
WO-2007078335-A2 BIARYL NITROGEN HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION DECODE GENETICS, EHF. (IS) 2007-07-12 WO disclosed
US-20070149544-A1 BIARYL NITROGEN-HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION DECODE CHEMISTRY, INC. (US) 2007-06-28 US disclosed
US-20070149544-A1 BIARYL NITROGEN-HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION DECODE CHEMISTRY, INC. (US) 2007-06-28 US disclosed
EP-1138678-B1 Process for making N-((4-phenyl) methylphenyl) piperazines DAIICHI SUNTORY PHARMA CO LTD (JP) 2004-12-22 EP disclosed
EP-1138678-A3 Process for making N-((4-phenyl) methylphenyl) piperazines SUNTORY LIMITED (JP) 2001-10-17 EP disclosed
EP-1138678-A2 Process for making N-((4-phenyl) methylphenyl) piperazines SUNTORY LIMITED (JP) 2001-10-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200253958-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE PCSK9, LDLR, PCSK7 SIGMAR1 2304/4885ADRB1 1401/4885HTR3E 1341/4885
US-20070149544-A1 BIARYL NITROGEN-HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION LTA4H, LTC4S, LTB4R SIGMAR1 2860/4885ADRB1 1432/4885HTR3E 1632/4885
US-20220047582-A1 PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE PCSK9, LDLR, PCSK7 SIGMAR1 2304/4885ADRB1 1401/4885HTR3E 1341/4885
US-10980801-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use PCSK9, LDLR, PCSK7 SIGMAR1 2304/4885ADRB1 1401/4885HTR3E 1341/4885
US-11925637-B2 Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use PCSK9, LDLR, PCSK7 SIGMAR1 2304/4885ADRB1 1401/4885HTR3E 1341/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.