Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 6/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MLNR | O43193 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | ME2 | P23368 | 1/20 | 0.39 |
| ▸ | ME1 | P48163 | 1/20 | 0.39 |
| ▸ | ME3 | Q16798 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30457448 | 0.88 | MC4R (0.70) | MC4RKCNH2ALDH1A1SMN1; SMN2MLNR | |
| SCHEMBL25272696 | 0.88 | MC4R (0.70) | MC4RKCNH2ALDH1A1SMN1; SMN2MLNR | |
| SCHEMBL31666902 | 0.82 | MC4R (0.72) | MC4RKCNH2ALDH1A1SMN1; SMN2MLNR | |
| SCHEMBL25228967 | 0.82 | MC4R (0.60) | MC4RKCNH2ALDH1A1SMN1; SMN2MLNR | |
| SCHEMBL31666906 | 0.79 | MC4R (0.72) | MC4RKCNH2ALDH1A1SMN1; SMN2MLNR | |
| SCHEMBL25225367 | 0.76 | ALDH1A1 (0.57) | MC4RKCNH2ALDH1A1SMN1; SMN2MLNR | |
| SCHEMBL31666899 | 0.76 | MC4R (0.65) | MC4RKCNH2ALDH1A1SMN1; SMN2MLNR | |
| SCHEMBL25277642 | 0.75 | USP30 (0.47) | ALDH1A1NPC1RAB9ASYK | |
| SCHEMBL12248697 | 0.71 | SYK (0.51) | MC4RKCNH2ALDH1A1SYK | |
| SCHEMBL31666891 | 0.71 | MC4R (0.59) | MC4RKCNH2MLNRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4444708-B1 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | PFIZER (US) | 2025-07-30 | — | — | EP | disclosed |
| US-20250129048-A1 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | PFIZER INC. (US) | 2025-04-24 | — | — | US | disclosed |
| EP-4444708-A1 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | Pfizer Inc. (US) | 2024-10-16 | — | — | EP | disclosed |
| CN-118369317-A | Melanocortin 4 receptor antagonists and uses thereof | 辉瑞大药厂 | 2024-07-19 | — | — | CN | disclosed |
| WO-2023105387-A1 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | PFIZER INC. (US) | 2023-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250129048-A1 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | MC4R, MC3R, MC2R | MC4R 1/4885KCNH2 3260/4885ALDH1A1 3955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.