Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25409013 | 0.85 | PKM (0.64) | PKMPOLBHPGDLMNAALDH1A1 | |
| SCHEMBL11166353 | 0.82 | RAD52 (0.58) | LMNAALDH1A1TSHRKDM4EMAPT | |
| SCHEMBL25408131 | 0.81 | PKM (0.65) | PKMPOLBHPGDALDH1A1HTR1A | |
| SCHEMBL3068737 | 0.81 | DRD3 (0.54) | PKMPOLBLMNAALDH1A1HTR1A | |
| Hydrochloric Acid SCHEMBL11079318 | 0.80 | DRD2 (0.58) | PKMALDH1A1HTR1AHTR7DRD2 | |
| SCHEMBL13648743 | 0.80 | POLB (0.65) | PKMPOLBLMNAALDH1A1HTR1A | |
| SCHEMBL11081882 | 0.80 | PKM (0.60) | PKMHPGDLMNAALDH1A1HTR1A | |
| Hydrochloric Acid SCHEMBL11088272 | 0.80 | DRD3 (0.59) | ALDH1A1HTR1AHTR7DRD2DRD3 | |
| SCHEMBL3252759 | 0.79 | PKM (0.78) | PKMHPGDLMNAALDH1A1TSHR | |
| SCHEMBL3068873 | 0.79 | HTR1A (0.68) | PKMALDH1A1HTR1ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183227-B1 | 1,2,4-TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LTD (GB) | 2014-09-24 | — | — | EP | disclosed |
| EP-2183227-B1 | 1,2,4-TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LTD (GB) | 2014-09-24 | — | — | EP | disclosed |
| US-8222254-B2 | 1, 2, 4-triazole derivatives as serotonergic modulators | PROSARIX LIMITED (GB) | 2012-07-17 | — | — | US | disclosed |
| US-8222254-B2 | 1, 2, 4-triazole derivatives as serotonergic modulators | PROSARIX LIMITED (GB) | 2012-07-17 | — | — | US | disclosed |
| US-8222254-B2 | 1, 2, 4-triazole derivatives as serotonergic modulators | PROSARIX LIMITED (GB) | 2012-07-17 | — | — | US | disclosed |
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED | 2010-10-14 | — | — | US | disclosed |
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED | 2010-10-14 | — | — | US | disclosed |
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED | 2010-10-14 | — | — | US | disclosed |
| EP-2183227-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | Prosarix Limited (GB) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009019472-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED (GB) | 2009-02-12 | — | — | WO | disclosed |
| WO-2009019472-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED (GB) | 2009-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | HTR1A, HTR5A, TPH1 | PKM 1377/4885POLB 4561/4885HPGD 1445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.