SCHEMBL30459565

SCHEMBL30459565

[2H]N1Cc2cc(CO)cc(F)c2C1=O

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.32
HTR2C P28335 1/20 0.32
HTR2B P41595 1/20 0.32
MKNK2 Q9HBH9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30459611 0.68 SRD5A1 (0.44) HTR2CHTR2B
SCHEMBL30268443 0.68 NTRK2 (0.35) HTR2AHTR2CHTR2B
SCHEMBL12490350 0.66 RXRA (0.37)
SCHEMBL27085852 0.66 GRM2 (0.44)
SCHEMBL3836776 0.65 AURKA (0.34)
SCHEMBL4813745 0.64 MAOA (0.34)
SCHEMBL16080734 0.63 KIF11 (0.38)
SCHEMBL24667786 0.61 MKNK2 (0.41) MKNK2
SCHEMBL29987052 0.61 MKNK2 (0.41) MKNK2
SCHEMBL16953925 0.61 ACHE (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023104155-A1 LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF 标新生物医药科技(上海)有限公司 2023-06-15 WO disclosed