Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 11/20 | 0.51 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.47 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | IL2 | P60568 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15328156 | 1.00 | TGFBR1 (0.54) | TGFBR1ACVR1ACVR1BADRB1HTR3E | |
| SCHEMBL15328365 | 0.96 | CHRNB2 (0.51) | TGFBR1ACVR1ACVR1BADRB1HTR3E | |
| SCHEMBL1304918 | 0.89 | MTOR (0.52) | TGFBR1ACVR1IL2MAP4K1PIM1 | |
| SCHEMBL17550807 | 0.85 | ADRB1 (0.45) | TGFBR1ACVR1ACVR1BADRB1KCNH2 | |
| SCHEMBL617761 | 0.84 | TGFBR1 (0.48) | TGFBR1ACVR1MAP4K1DDR1KCNH2 | |
| SCHEMBL618561 | 0.83 | MAP4K1 (0.49) | TGFBR1ACVR1MAP4K1 | |
| SCHEMBL615975 | 0.82 | EHMT2 (0.40) | TGFBR1PIM1ABL1 | |
| SCHEMBL1304390 | 0.82 | PDGFRB (0.51) | — | |
| SCHEMBL619713 | 0.80 | ACHE (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL15327927 | 0.80 | ACVR1 (0.47) | TGFBR1ACVR1ACVR1BBMPR1AACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |