Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | GHSR | Q92847 | 10/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | KHK | P50053 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30459652 | 0.84 | TGFBR1 (0.54) | TGFBR1ACVR1KCNH2DDR1MAP4K1 | |
| SCHEMBL15328156 | 0.84 | TGFBR1 (0.54) | TGFBR1ACVR1KCNH2DDR1MAP4K1 | |
| SCHEMBL1304918 | 0.82 | MTOR (0.52) | TGFBR1ACVR1KDRKDM4EALDH1A1 | |
| SCHEMBL15328365 | 0.80 | CHRNB2 (0.51) | TGFBR1ACVR1MAP4K1 | |
| SCHEMBL1304390 | 0.79 | PDGFRB (0.51) | MAOAMAOBPDGFRBKDM4EMEN1 | |
| SCHEMBL616991 | 0.79 | SUV39H2 (0.42) | PDGFRBPDGFRANTSR1 | |
| SCHEMBL615975 | 0.77 | EHMT2 (0.40) | TGFBR1FGFR1KDRFGFR4PDGFRB | |
| SCHEMBL618561 | 0.77 | MAP4K1 (0.49) | TGFBR1ACVR1FGFR1KDRFGFR4 | |
| SCHEMBL346309 | 0.76 | PDGFRB (0.50) | KDRPDGFRBKDM4EMEN1ALDH1A1 | |
| SCHEMBL15533402 | 0.76 | ALDH1A1 (0.48) | MAOAMAOBPDGFRBKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040954-A1 | NOVEL ANTI-INFLAMMATORY AGENTS | HEPALINK (HONG KONG) LIMITED (HK) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040954-A1 | NOVEL ANTI-INFLAMMATORY AGENTS | VCAM1, ICAM1, IL6 | TGFBR1 699/4885ACVR1 2523/4885KCNH2 3043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.