Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 10/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | RARB | P10826 | 2/20 | 0.38 |
| ▸ | RARG | P13631 | 2/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | RARA | P10276 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ASPH | Q12797 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31335591 | 0.82 | ATAD2 (0.42) | PGRATAD2PDK2PDK4PDE3B | |
| SCHEMBL31335589 | 0.82 | ATAD2 (0.42) | PGRATAD2PDK2PDK4PDE3B | |
| SCHEMBL4882002 | 0.82 | PGR (0.43) | PGRIP6K1ATAD2PDK2PDK4 | |
| SCHEMBL23577902 | 0.81 | ATAD2 (0.41) | PGRATAD2PDK2PDK4PDE3B | |
| SCHEMBL30035471 | 0.81 | ATAD2 (0.41) | PGRATAD2PDK2PDK4PDE3B | |
| SCHEMBL25156363 | 0.79 | MAPK14 (0.46) | PGRATAD2PDK2PDK4PDE3B | |
| SCHEMBL31335972 | 0.78 | ALDH1A1 (0.44) | PGRATAD2PDK2PDK4PDE3B | |
| SCHEMBL16858573 | 0.75 | PGR (0.46) | PGRATAD2PDK2PDK4PDE3B | |
| SCHEMBL30459912 | 0.72 | PGR (0.44) | PGRATAD2PDK2PDK4PDE3B | |
| SCHEMBL24251754 | 0.71 | PGR (0.49) | PGRATAD2PDK2PDK4PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116457346-A | Preparation of indolone derivatives as novel diacylglycerol O-acyltransferase 2 inhibitors | 默沙东有限责任公司 | 2023-07-18 | — | — | CN | disclosed |