Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 14/20 | 0.58 |
| ▸ | WDR48 | Q8TAF3 | 14/20 | 0.58 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26627798 | 1.00 | USP1 (0.58) | USP1WDR48PIP4K2CTRPM8LMNA | |
| SCHEMBL26627842 | 0.81 | P2RX3 (0.51) | USP1WDR48 | |
| SCHEMBL30462096 | 0.81 | P2RX3 (0.51) | USP1WDR48 | |
| SCHEMBL31423632 | 0.75 | USP1 (0.75) | USP1WDR48PIP4K2C | |
| SCHEMBL31423562 | 0.74 | USP1 (0.70) | USP1WDR48 | |
| SCHEMBL31423660 | 0.74 | USP1 (0.65) | USP1WDR48 | |
| SCHEMBL31423519 | 0.74 | USP1 (0.67) | USP1WDR48PIP4K2C | |
| SCHEMBL23837648 | 0.73 | TRPM8 (0.73) | TRPM8LMNASMN1; SMN2MITFMAPT | |
| SCHEMBL31423616 | 0.73 | TRPM8 (0.64) | USP1WDR48PIP4K2CTRPM8LMNA | |
| SCHEMBL31423567 | 0.72 | USP1 (0.66) | USP1WDR48PIP4K2CTRPM8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118660872-A | Pyrimidine compound, preparation method and medical application thereof | 江苏亚虹医药科技股份有限公司 | 2024-09-17 | — | — | CN | disclosed |
| CN-116496252-A | Pyrimidine compound, preparation method and medical application thereof | 江苏亚虹医药科技股份有限公司 | 2023-07-28 | — | — | CN | disclosed |