SCHEMBL3046225

SCHEMBL3046225

COc1ccc(S(=O)(=O)N2CCc3cc(O)c(OC)cc3C2=O)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 3/20 0.54
MMP1 P03956 2/20 0.54
MMP7 P09237 2/20 0.54
MMP9 P14780 2/20 0.54
MMP12 P39900 2/20 0.54
MMP14 P50281 2/20 0.54
MMP15 P51511 2/20 0.54
MMP16 P51512 2/20 0.54
MMP26 Q9NRE1 2/20 0.54
PKM P14618 2/20 0.51
TUBB4A P04350 1/20 0.47
TUBB P07437 1/20 0.47
TUBA3C P0DPH7 1/20 0.47
TUBA1B P68363 1/20 0.47
TUBA4A P68366 1/20 0.47
TUBB4B P68371 1/20 0.47
TUBB3 Q13509 1/20 0.47
TUBB2A Q13885 1/20 0.47
TUBB8 Q3ZCM7 1/20 0.47
TUBA3E Q6PEY2 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3051781 0.88 PKM (0.48) MMP2MMP1MMP7MMP9MMP12
SCHEMBL3052679 0.88 CYP11B1 (0.51) MMP2MMP1MMP7MMP9MMP12
SCHEMBL3051277 0.82 MMP2 (0.46) MMP2MMP1MMP7MMP9MMP12
SCHEMBL3061756 0.81 TSHR (0.48) MMP2MMP1MMP7MMP9MMP12
SCHEMBL3060108 0.80 CHRNA7 (0.50) MMP2MMP1MMP7MMP9MMP12
SCHEMBL3059338 0.79 GAA (0.49) MMP2MMP1MMP7MMP9MMP12
SCHEMBL3050420 0.78 MMP1 (0.44) MMP2MMP1MMP7MMP9MMP12
SCHEMBL3061348 0.78 PKM (0.84) MMP2MMP1MMP7MMP9MMP12
SCHEMBL3057016 0.77 CA2 (0.60) MMP2MMP1MMP7MMP9MMP12
SCHEMBL3059107 0.76 CYP11B1 (0.48) PKMPKLRPDE4BPDE4DPDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100222299-A1 COMPOUND STERIX LIMITED (GB) 2010-09-02 US claimed
US-8394825-B2 Compound STERIX LIMITED (GB) 2013-03-12 US disclosed
US-20100222299-A1 COMPOUND STERIX LIMITED (GB) 2010-09-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100222299-A1 COMPOUND MKI67, VHL, MYC MMP2 292/4885MMP1 1682/4885MMP7 816/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.