Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 9/20 | 0.41 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3053153 | 0.93 | HTR6 (0.38) | HTR6BDKRB1OPRM1OPRL1OPRD1 | |
| SCHEMBL3046839 | 0.81 | BDKRB1 (0.35) | BDKRB1OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL3053633 | 0.77 | KMO (0.46) | HTR6MTNR1AMTNR1BGAAMAPT | |
| SCHEMBL3049703 | 0.76 | HTR6 (0.36) | HTR6BDKRB1OPRD1OPRK1 | |
| SCHEMBL13139524 | 0.75 | HTR6 (0.46) | HTR6MTNR1AMTNR1BGAAMAPT | |
| SCHEMBL3047591 | 0.75 | AVPR1B (0.37) | BDKRB1OPRM1OPRL1MAPTOPRD1 | |
| SCHEMBL3052593 | 0.74 | HTR6 (0.38) | HTR6BDKRB1 | |
| SCHEMBL3406609 | 0.73 | BDKRB1 (0.57) | BDKRB1 | |
| SCHEMBL3053112 | 0.72 | ALDH1A1 (0.46) | HTR6MTNR1AMTNR1BGAAMAPT | |
| SCHEMBL3050887 | 0.71 | MTNR1A (0.40) | HTR6MTNR1AMTNR1BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | claimed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | BDKRB1, BDKRB2, EDNRB | HTR6 103/4885BDKRB1 1/4885OPRM1 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.