Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.58 |
| ▸ | CYP3A5 | P20815 | 3/20 | 0.58 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.51 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20818634 | 1.00 | CYP3A4 (0.58) | CYP3A4CYP3A5GPR119PLA2G7MGLL | |
| SCHEMBL14035283 | 0.91 | CYP3A4 (0.58) | CYP3A4CYP3A5GPR119PLA2G7MGLL | |
| SCHEMBL15093706 | 0.86 | CYP3A4 (0.71) | CYP3A4CYP3A5GPR119PLA2G7MGLL | |
| SCHEMBL31071488 | 0.86 | CYP3A4 (0.71) | CYP3A4CYP3A5GPR119PLA2G7MGLL | |
| SCHEMBL38661641 | 0.86 | GPR119 (0.49) | CYP3A4CYP3A5GPR119ALDH1A1MAPT | |
| SCHEMBL7985622 | 0.86 | GAA (0.50) | GPR119MGLLKDM4EALDH1A1MAPT | |
| SCHEMBL210120 | 0.85 | CYP3A4 (0.61) | CYP3A4CYP3A5GPR119PLA2G7MGLL | |
| SCHEMBL25241482 | 0.83 | TP53 (0.52) | CYP3A4CYP3A5TP53KDM4EALDH1A1 | |
| SCHEMBL19668681 | 0.83 | CYP3A4 (0.59) | CYP3A4CYP3A5GPR119PLA2G7MGLL | |
| SCHEMBL29363322 | 0.83 | CYP3A4 (0.59) | CYP3A4CYP3A5GPR119PLA2G7MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12435078-B2 | Pyridazinones and methods of use thereof | GFB (ABC), LLC (US) | 2025-10-07 | — | — | US | disclosed |
| US-20230203028-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GFB (ABC), LLC | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203028-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | PDXK, ATP6V1B1, REN | CYP3A4 101/4885CYP3A5 53/4885GPR119 846/4885 |
| US-12435078-B2 | Pyridazinones and methods of use thereof | PDXK, ATP6V1B1, REN | CYP3A4 101/4885CYP3A5 53/4885GPR119 846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.