Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | GOT1 | P17174 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MPO | P05164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.47 |
| ▸ | ACOX1 | Q15067 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL600018 | 0.89 | KDM4E (0.57) | KDM4ELMNATP53CYP3A4GOT1 | |
| SCHEMBL29560277 | 0.89 | KDM4E (0.57) | KDM4ELMNATP53CYP3A4GOT1 | |
| Hydrochloric Acid SCHEMBL27687770 | 0.87 | KDM4E (0.58) | KDM4ELMNATP53CYP3A4GOT1 | |
| Trifluoroacetic Acid SCHEMBL29015415 | 0.80 | C1S (0.62) | KDM4ELMNATP53CYP3A4GOT1 | |
| Formic Acid SCHEMBL30214020 | 0.79 | ERN1 (0.41) | KDM4ELMNACYP3A4ALDH1A1CYP1A2 | |
| Formic Acid SCHEMBL30994748 | 0.79 | ERN1 (0.38) | KDM4ELMNACYP3A4ALDH1A1CYP1A2 | |
| Chlorobenzene SCHEMBL27514649 | 0.79 | KDM4E (0.47) | KDM4ELMNATP53CYP3A4GOT1 | |
| Formic Acid SCHEMBL30738145 | 0.73 | F12 (0.78) | LMNACYP3A4SMN1; SMN2NPC1RAB9A | |
| SCHEMBL224748 | 0.72 | NPC1 (0.47) | KDM4ELMNATP53CYP3A4GOT1 | |
| Formic Acid SCHEMBL30452445 | 0.71 | LCK (0.41) | KDM4ELMNATP53SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12304915-B2 | SOS1 inhibitors | Mirati Therapeutics, Inc. (US) | 2025-05-20 | — | — | US | disclosed |
| US-20250059182-A1 | SOS1 INHIBITORS | MIRATI THERAPEUTICS, INC | 2025-02-20 | — | — | US | disclosed |
| US-20230137886-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12304915-B2 | SOS1 inhibitors | SOS1, SOS2, SAV1 | KDM4E 3245/4885LMNA 3751/4885TP53 194/4885 |
| US-20250059182-A1 | SOS1 INHIBITORS | SOS1, SOS2, SOST | KDM4E 2892/4885LMNA 3902/4885TP53 447/4885 |
| US-20230137886-A1 | SOS1 INHIBITORS | SOS1, SOS2, SAV1 | KDM4E 3245/4885LMNA 3751/4885TP53 194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.