Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25358826 | 1.00 | HSD11B1 (0.40) | HSD11B1POLBMAPTEGFRPTGES | |
| SCHEMBL30690334 | 0.86 | EGFR (0.37) | EGFRPTGESDHODH | |
| SCHEMBL30495292 | 0.85 | PTGES (0.51) | HSD11B1MAPTPTGESALDH1A1TNKS | |
| SCHEMBL25360457 | 0.85 | PTGES (0.51) | HSD11B1MAPTPTGESALDH1A1TNKS | |
| SCHEMBL25362087 | 0.83 | KMT2A (0.45) | MAPTALDH1A1TP53TNKS2RAB9A | |
| SCHEMBL25359367 | 0.82 | DHODH (0.40) | HSD11B1DHODH | |
| SCHEMBL30494985 | 0.82 | PTGES (0.37) | EGFRPTGESALDH1A1 | |
| SCHEMBL25358018 | 0.82 | PTGES (0.37) | EGFRPTGESALDH1A1 | |
| SCHEMBL25359782 | 0.82 | ADORA2B (0.43) | EGFRALDH1A1ADORA2AADORA1 | |
| SCHEMBL30494909 | 0.82 | ADORA2B (0.43) | EGFRALDH1A1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |