Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.56 |
| ▸ | CTSG | P08311 | 1/20 | 0.56 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.56 |
| ▸ | CMA1 | P23946 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | NAAA | Q02083 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12093592 | 0.88 | LMNA (0.78) | LMNAPOLBSMN1; SMN2NPSR1NPC1 | |
| SCHEMBL3192014 | 0.88 | LMNA (0.77) | LMNAPOLBGAASMN1; SMN2NPC1 | |
| SCHEMBL28683804 | 0.87 | HDAC6 (0.68) | LMNAPOLBGAASMN1; SMN2NPC1 | |
| SCHEMBL9407545 | 0.87 | HDAC4 (0.62) | LMNAPOLBNPC1RAB9AEPHX2 | |
| SCHEMBL12089971 | 0.84 | RAB9A (0.64) | LMNAPOLBGAASMN1; SMN2NPC1 | |
| SCHEMBL321556 | 0.82 | LMNA (0.75) | LMNAPOLBGAASMN1; SMN2NPC1 | |
| SCHEMBL18689914 | 0.82 | LMNA (0.69) | LMNAPOLBGAASMN1; SMN2NPC1 | |
| SCHEMBL3565228 | 0.82 | EPHX1 (0.54) | LMNAPOLBSMN1; SMN2EPHX2HDAC4 | |
| SCHEMBL6629558 | 0.82 | SMN1; SMN2 (0.51) | LMNAPOLBGAASMN1; SMN2NPSR1 | |
| SCHEMBL4292042 | 0.81 | HPGDS (0.62) | LMNAPOLBSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772388-B2 | Inhibition of metallo-β-lactamase | TEXAS TECH UNIVERSITY (US) | 2010-08-10 | — | — | US | disclosed |
| US-20090203003-A1 | INHIBITION OF METALLO-BETA-LACTAMASE | TEXAS TECH UNIVERSITY SYSTEM (US) | 2009-08-13 | — | — | US | disclosed |