Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3050071 | 0.82 | LMNA (0.62) | SMN1; SMN2NPC1RAB9AMAPTHDAC4 | |
| SCHEMBL5648430 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL28095336 | 0.78 | HPGD (0.72) | SMN1; SMN2NPC1RAB9ACA2HDAC1 | |
| SCHEMBL12093592 | 0.78 | LMNA (0.78) | SMN1; SMN2NPC1RAB9AMAPTHDAC4 | |
| SCHEMBL9407545 | 0.77 | HDAC4 (0.62) | NPC1RAB9AHDAC4HDAC1HDAC6 | |
| SCHEMBL5843937 | 0.76 | CTSK (0.38) | NPC1RAB9ACA12CA1CA2 | |
| SCHEMBL6629998 | 0.74 | MLYCD (0.58) | SMN1; SMN2NPC1RAB9APOLBKMT2A | |
| SCHEMBL12089971 | 0.74 | RAB9A (0.64) | SMN1; SMN2NPC1RAB9AMAPTHDAC4 | |
| SCHEMBL12421889 | 0.74 | NPC1 (0.49) | SMN1; SMN2NPC1RAB9ACA12CA1 | |
| SCHEMBL6629738 | 0.74 | RAB9A (0.69) | SMN1; SMN2NPC1RAB9APOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |