Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.50 |
| ▸ | DRD3 | P35462 | 5/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11348398 | 0.82 | HTR2A (0.41) | DRD2DRD3OPRK1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL25287000 | 0.81 | PNMT (0.42) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL4263745 | 0.70 | DRD2 (0.64) | DRD2DRD3OPRK1PLAUADRA2A | |
| SCHEMBL10618547 | 0.70 | MAPT (0.56) | DRD2DRD3OPRK1PLAU | |
| SCHEMBL11578773 | 0.69 | ACHE (0.38) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| Bromide SCHEMBL7200937 | 0.69 | DRD2 (0.62) | DRD2DRD3OPRK1PLAUADRA2A | |
| SCHEMBL11884613 | 0.68 | MAPT (0.64) | DRD2DRD3OPRK1PLAU | |
| SCHEMBL11358755 | 0.68 | ADRA1A (0.34) | DRD2DRD3OPRK1PLAUADRA1A | |
| SCHEMBL11359509 | 0.68 | ADRA1A (0.34) | DRD2DRD3OPRK1ADRA1A | |
| SCHEMBL24095373 | 0.68 | ADRA1A (0.38) | DRD2DRD3OPRK1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100143322-A1 | USE OF INHIBITORS OF N-METHYL TRANSFERASES FOR THE THERAPY OF PARKINSON'S DISEASE | PLT PATENT & LICENCE TRADING LTD., C/O THE B-NET (GB) | 2010-06-10 | — | — | US | claimed |
| US-20100143322-A1 | USE OF INHIBITORS OF N-METHYL TRANSFERASES FOR THE THERAPY OF PARKINSON'S DISEASE | PLT PATENT & LICENCE TRADING LTD., C/O THE B-NET (GB) | 2010-06-10 | — | — | US | disclosed |
| US-3919316-A | 2-Aminodichlorotetralins | LILLY CO ELI | 1975-11-11 | — | — | US | disclosed |