Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 4/20 | 0.51 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | PRKACA | P17612 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828027 | 0.87 | PIM1 (0.47) | SIRT2PIM1CDK2ROCK2PRKACA | |
| SCHEMBL5828735 | 0.78 | PIM1 (0.54) | SIRT2PIM1CDK2ROCK2PRKACA | |
| SCHEMBL7193605 | 0.72 | SIRT2 (1.00) | SIRT2PIM1CDK2PRKACACDK9 | |
| SCHEMBL5879226 | 0.71 | FLT3 (0.57) | SIRT2PIM1CDK2ROCK2PRKACA | |
| SCHEMBL5828525 | 0.70 | SIRT2 (0.59) | SIRT2PIM1CDK2PRKACAGSK3B | |
| SCHEMBL17210880 | 0.70 | PIM1 (0.50) | PIM1CDK2ROCK2PRKACAGSK3B | |
| Tert-Butyl Formate SCHEMBL27610429 | 0.70 | PIM1 (0.45) | SIRT2PIM1CDK2KDRFLT3 | |
| SCHEMBL3065646 | 0.69 | ELANE (0.61) | GSK3BCYP1B1 | |
| SCHEMBL16705131 | 0.69 | FLT3 (0.67) | SIRT2PIM1CDK2ROCK2PRKACA | |
| SCHEMBL13204318 | 0.69 | PIM1 (0.54) | SIRT2PIM1CDK2ROCK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470849-B2 | 7-azaindole derivatives as selective 11-β-hydroxysteroid dehydrogenase type 1 inhibitors | MERCK PATENT GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| US-8470849-B2 | 7-azaindole derivatives as selective 11-β-hydroxysteroid dehydrogenase type 1 inhibitors | MERCK PATENT GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| US-8470849-B2 | 7-azaindole derivatives as selective 11-β-hydroxysteroid dehydrogenase type 1 inhibitors | MERCK PATENT GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| EP-2247589-B1 | 7-AZAINDOLE DERIVATIVES AS SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | MERCK PATENT GMBH (DE) | 2012-11-21 | — | — | EP | disclosed |
| US-20100267761-A1 | 7-Azaindole Derivatives as Selective 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors | MERCK PATENT GESELLSCHAFT | 2010-10-21 | — | — | US | disclosed |
| US-20100267761-A1 | 7-Azaindole Derivatives as Selective 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors | MERCK PATENT GESELLSCHAFT | 2010-10-21 | — | — | US | disclosed |
| US-20100267761-A1 | 7-Azaindole Derivatives as Selective 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors | MERCK PATENT GESELLSCHAFT | 2010-10-21 | — | — | US | disclosed |
| WO-2009059666-A1 | 7-AZAINDOLE DERIVATIVES AS SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | MERCK PATENT GMBH (DE) | 2009-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267761-A1 | 7-Azaindole Derivatives as Selective 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors | HSD11B1, HSD17B1, HSD11B2 | SIRT2 2301/4885PIM1 4103/4885CDK2 2692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.