Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 4/20 | 0.43 |
| ▸ | PRKACG | P22612 | 4/20 | 0.43 |
| ▸ | PRKACB | P22694 | 4/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.43 |
| ▸ | PRKCB | P05771 | 2/20 | 0.43 |
| ▸ | PRKCA | P17252 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | PRKCH | P24723 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9374063 | 0.92 | SIRT2 (0.70) | SIRT2SIRT1PRKACAPRKACGPRKACB | |
| SCHEMBL3971688 | 0.87 | TRPM8 (0.46) | SIRT2ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL5828027 | 0.85 | PIM1 (0.47) | SIRT2PRKACAPIM1CDK1CAMK2D | |
| SCHEMBL5828559 | 0.77 | ALDH1A1 (0.49) | GSK3BALDH1A1 | |
| SCHEMBL1395830 | 0.75 | SIRT2 (0.55) | SIRT2SIRT1PRKACAPRKACGPRKACB | |
| SCHEMBL14560474 | 0.75 | SIRT2 (0.56) | SIRT2SIRT1PRKACAPRKACGPRKACB | |
| SCHEMBL13169903 | 0.75 | RPS6KB1 (0.51) | SIRT2SIRT1PRKACAPRKACGPRKACB | |
| SCHEMBL7193605 | 0.75 | SIRT2 (1.00) | SIRT2SIRT1PRKACAPRKACGPRKACB | |
| SCHEMBL5827925 | 0.75 | SIRT2 (0.48) | SIRT2SIRT1PRKACAPRKACGPRKACB | |
| SCHEMBL28101324 | 0.75 | CAMK2D (0.48) | SIRT2SIRT1PRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110218206-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2022-03-04 | — | — | CN | disclosed |
| CN-110526903-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2021-12-10 | — | — | CN | disclosed |
| CN-110526903-A | Bisindole maleimide derivative and its preparation method and application | OCEAN UNIV CHINA | 2019-12-03 | — | — | CN | disclosed |
| CN-110218206-A | Bisindole maleimide derivative and its preparation method and application | 中国海洋大学 | 2019-09-10 | — | — | CN | disclosed |
| CN-106083830-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2019-07-12 | — | — | CN | disclosed |
| CN-106146475-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2019-05-17 | — | — | CN | disclosed |
| CN-106146475-A | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2016-11-23 | — | — | CN | disclosed |
| CN-106083830-A | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2016-11-09 | — | — | CN | disclosed |
| US-7001906-B2 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | LES LABORATOIRES SERVIER (FR) | 2006-02-21 | — | — | US | disclosed |
| US-20040152721-A1 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | LES LABORATOIRES SERVIER (FR) | 2004-08-05 | — | — | US | disclosed |
| EP-1409486-A1 | PYRIDO-PYRIDO-PYRROLO PYRROLO-INDOLE AND PYRIDO-PYRROLO PYRROLO CARBAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | LES LABORATOIRES SERVIER (FR) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003002563-A1 | PYRIDO-PYRIDO-PYRROLO PYRROLO-INDOLE AND PYRIDO-PYRROLO PYRROLO CARBAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | LES LABORATOIRES SERVIER (FR) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152721-A1 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | PYM1, PNPO, IDO1 | SIRT2 883/4885SIRT1 674/4885PRKACA 2590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.