Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 7/20 | 0.64 |
| ▸ | DRD2 | P14416 | 5/20 | 0.64 |
| ▸ | DRD3 | P35462 | 3/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 2/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | MAOA | P21397 | 2/20 | 0.60 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3057653 | 0.83 | DRD2 (0.61) | DRD1DRD2DRD3SIGMAR1MAOA | |
| SCHEMBL3057030 | 0.82 | CA2 (0.66) | DRD1DRD2DRD3SIGMAR1CA9 | |
| SCHEMBL27715262 | 0.82 | DRD1 (0.52) | DRD1DRD2DRD3SIGMAR1CA9 | |
| SCHEMBL3051846 | 0.79 | CHRNA7 (0.54) | DRD1DRD2DRD3SIGMAR1DHFR | |
| SCHEMBL8034415 | 0.76 | MAOA (0.97) | DRD1DRD2DRD3MAOAALDH1A1 | |
| SCHEMBL14740349 | 0.76 | DRD2 (0.61) | DRD1DRD2DRD3SIGMAR1MAOA | |
| SCHEMBL28742794 | 0.76 | DRD2 (0.56) | DRD1DRD2DRD3SIGMAR1MAOA | |
| SCHEMBL10658249 | 0.76 | MAOA (0.57) | DRD1DRD2DRD3SIGMAR1MAOA | |
| SCHEMBL11625663 | 0.76 | DRD2 (0.45) | DRD1DRD2DRD3SIGMAR1CA9 | |
| SCHEMBL3052491 | 0.76 | CA9 (0.60) | DRD1DRD2DRD3SIGMAR1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155192-B1 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | STERIX LTD (GB) | 2016-09-28 | — | — | EP | disclosed |
| US-8394825-B2 | Compound | STERIX LIMITED (GB) | 2013-03-12 | — | — | US | disclosed |
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222299-A1 | COMPOUND | MKI67, VHL, MYC | DRD1 3150/4885DRD2 2317/4885DRD3 3408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.