Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3047546 | 0.92 | HTT (0.40) | HTTNAMPTHPGDHDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL3047191 | 0.86 | HDAC1 (0.45) | HTTNAMPTHDAC1HDAC2HDAC3 | |
| SCHEMBL13136891 | 0.82 | HTT (0.49) | HTTNAMPTP2RY14 | |
| Trifluoroacetic Acid SCHEMBL3047291 | 0.81 | HTR5A (0.41) | ADRB1ADRB3P2RY14NOD2NOD1 | |
| Trifluoroacetic Acid SCHEMBL3046284 | 0.81 | TAAR1 (0.41) | NAMPTNOD2NOD1 | |
| SCHEMBL3051661 | 0.80 | HTT (0.36) | HTTRARBADRB1ADRB3NAMPT | |
| Trifluoroacetic Acid SCHEMBL1875536 | 0.80 | HTT (0.41) | HTTNAMPT | |
| Trifluoroacetic Acid SCHEMBL3045182 | 0.78 | HDAC1 (0.43) | HTTHDAC1 | |
| Trifluoroacetic Acid SCHEMBL3042666 | 0.77 | ALDH1A1 (0.42) | RARBP2RY14HPGDNOD2NOD1 | |
| SCHEMBL13136885 | 0.74 | HTT (0.47) | HTTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222345-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS | SMITHKLINE BEECHAM CORPORATION | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222345-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS | OPRL1, OPRM1, OPRK1 | HTT 1472/4885RARB 441/4885ADRB1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.