Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3050294 | 0.86 | HDAC6 (0.42) | HTR5AROCK2ROCK1POLBRAB9A | |
| Hydrochloric Acid SCHEMBL3048543 | 0.84 | NFE2L2 (0.38) | ADRB1ADRB3ALDH1A1PDE3BPDE3A | |
| SCHEMBL13136892 | 0.84 | PIK3CA (0.44) | ADRB1ADRB3ALDH1A1ROCK2ROCK1 | |
| Trifluoroacetic Acid SCHEMBL3046203 | 0.82 | HTR5A (0.46) | HTR5A | |
| Trifluoroacetic Acid SCHEMBL3051658 | 0.81 | HTT (0.42) | ADRB1ADRB3P2RY14EPHX2HDAC6 | |
| Trifluoroacetic Acid SCHEMBL3044503 | 0.81 | HTR5A (0.44) | HTR5A | |
| Trifluoroacetic Acid SCHEMBL3829844 | 0.80 | HDAC6 (0.40) | HTR5AALDH1A1KDM4EPOLBHDAC6 | |
| Trifluoroacetic Acid SCHEMBL1872879 | 0.80 | HDAC6 (0.40) | HTR5AALDH1A1KDM4EPOLBHDAC6 | |
| Trifluoroacetic Acid SCHEMBL3042666 | 0.79 | ALDH1A1 (0.42) | HTR5AALDH1A1PPARDPPARAKDM4E | |
| SCHEMBL3047294 | 0.79 | ESR1 (0.37) | HTR5AALDH1A1PPARDPPARAP2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222345-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS | SMITHKLINE BEECHAM CORPORATION | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222345-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS | OPRL1, OPRM1, OPRK1 | HTR5A 190/4885ADRB1 9/4885ADRB3 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.