Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11293575 | 0.85 | ALDH1A1 (0.46) | P2RX7GAATHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL3051654 | 0.84 | P2RX7 (0.50) | P2RX7MAPTTHRBLMNATP53 | |
| Hydrochloric Acid SCHEMBL11299080 | 0.84 | ALDH1A1 (0.45) | P2RX7GAATHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL11297451 | 0.81 | ALDH1A1 (0.46) | P2RX7MAPTTHRBHTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL11294182 | 0.80 | ALDH1A1 (0.45) | P2RX7MAPTTHRBHTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL27699724 | 0.79 | HRH2 (0.46) | KMT2AKDM4EMAPTGAAL3MBTL1 | |
| SCHEMBL3047241 | 0.78 | SLC6A2 (0.55) | P2RX7KMT2AL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3040850 | 0.72 | DPP4 (0.46) | P2RX7LMNA | |
| SCHEMBL3260671 | 0.72 | LMNA (0.44) | KMT2AALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL11295525 | 0.71 | LMNA (0.44) | KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068794-A2 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2010-06-17 | — | — | WO | disclosed |