Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL218097 | 0.75 | ALDH1A1 (0.47) | ALDH1A1LMNAKLKB1POLBHPGD | |
| SCHEMBL3069571 | 0.73 | NR3C1 (0.39) | POLBHPGDHTT | |
| SCHEMBL3062042 | 0.66 | POLB (0.49) | ALDH1A1POLBHPGDHTTKDM4E | |
| SCHEMBL8955786 | 0.62 | ALDH1A1 (0.69) | ALDH1A1LMNAHPGDKDM4ETP53 | |
| SCHEMBL10359297 | 0.61 | ALDH1A1 (0.68) | ALDH1A1LMNAPOLBHPGDKDM4E | |
| SCHEMBL1073588 | 0.60 | RAB9A (0.47) | ALDH1A1LMNAKLKB1POLBHTT | |
| SCHEMBL2701799 | 0.60 | CNR1 (0.57) | POLBL3MBTL1KMT2A | |
| SCHEMBL9585652 | 0.59 | CYP1A2 (0.70) | ALDH1A1LMNAPOLBHPGDHTT | |
| SCHEMBL620675 | 0.59 | KDM4C (0.54) | ALDH1A1POLBHPGDHTTL3MBTL1 | |
| SCHEMBL6290092 | 0.58 | HPGD (1.00) | ALDH1A1LMNAPOLBHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267748-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS STEAROYL CoA DESATURASE INHIBITORS | GILEAD PALO ALTO, INC. (US) | 2010-10-21 | — | — | US | claimed |
| WO-2010045371-A1 | PYRIDO- AND PYRIMIDO (1, 2-A) PYRIMIDINE COMPOUNDS USEFUL AS STEAROYL COA DESATURASE INHIBITORS | GILEAD PALO ALTO, INC. (US) | 2010-04-22 | — | — | WO | claimed |
| US-20100267748-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS STEAROYL CoA DESATURASE INHIBITORS | GILEAD PALO ALTO, INC. (US) | 2010-10-21 | — | — | US | disclosed |
| WO-2010045371-A1 | PYRIDO- AND PYRIMIDO (1, 2-A) PYRIMIDINE COMPOUNDS USEFUL AS STEAROYL COA DESATURASE INHIBITORS | GILEAD PALO ALTO, INC. (US) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267748-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS STEAROYL CoA DESATURASE INHIBITORS | SCD, SCD5, FADS2 | ALDH1A1 293/4885LMNA 1721/4885KLKB1 4353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.