Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 16/20 | 0.44 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30545168 | 0.84 | IRAK4 (0.45) | IRAK4 | |
| SCHEMBL31661201 | 0.80 | PIM1 (0.40) | IRAK4CRHR1ACVR1BTGFBR1ACVRL1 | |
| SCHEMBL24508596 | 0.80 | IRAK4 (0.48) | IRAK4 | |
| SCHEMBL29709894 | 0.80 | IRAK4 (0.48) | IRAK4 | |
| SCHEMBL29709747 | 0.80 | IRAK4 (0.48) | IRAK4 | |
| SCHEMBL15110200 | 0.76 | AOC1 (0.50) | IRAK4ACVR1BTGFBR1 | |
| SCHEMBL31678742 | 0.74 | NUDT1 (0.51) | IRAK4TGFBR1 | |
| SCHEMBL29709731 | 0.73 | IRAK4 (0.43) | IRAK4 | |
| SCHEMBL621180 | 0.73 | CYP46A1 (0.52) | — | |
| SCHEMBL19691289 | 0.72 | PKM (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669722-A | Interleukin-1 receptor-related kinase (IRAK) degradants and uses thereof | 凯麦拉医疗公司 | 2023-08-29 | — | — | CN | disclosed |