Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 13/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.37 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30545154 | 0.80 | IRAK4 (0.44) | CRHR1IRAK4TGFBR1ACVR1BACVRL1 | |
| SCHEMBL31661162 | 0.73 | IRAK4 (0.71) | IRAK4 | |
| SCHEMBL30545168 | 0.71 | IRAK4 (0.45) | IRAK4 | |
| SCHEMBL13162007 | 0.66 | SIRT3 (0.53) | CRHR1 | |
| SCHEMBL19691289 | 0.65 | PKM (0.47) | — | |
| SCHEMBL15651270 | 0.64 | SMYD3 (0.49) | TGFBR1ACVRL1 | |
| SCHEMBL21041584 | 0.62 | DRD3 (0.61) | — | |
| SCHEMBL15110200 | 0.62 | AOC1 (0.50) | IRAK4TGFBR1ACVR1BCYP3A4 | |
| SCHEMBL14284660 | 0.62 | HPGDS (0.49) | CRHR1 | |
| SCHEMBL13162024 | 0.61 | RAB9A (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025151602-A1 | HETEROARYL COMPOUNDS AS LIGAND DIRECTED DEGRADERS OF IRAK4 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-07-17 | — | — | WO | disclosed |