Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2111731 | 0.81 | PGR (0.42) | PGRLOXL2CYP2A6ALDH1A1CA12 | |
| Hydrochloric Acid SCHEMBL15486318 | 0.79 | NOS3 (0.42) | PGRLOXL2CYP2A6ALDH1A1CA12 | |
| SCHEMBL13152861 | 0.78 | AKT1 (0.48) | AKT1AKT2 | |
| SCHEMBL2326687 | 0.76 | KCNH2 (0.42) | PGRLOXL2CYP2A6ALDH1A1CA12 | |
| SCHEMBL516251 | 0.76 | OPRM1 (0.45) | PGRCYP2A6ALDH1A1CA12CA2 | |
| SCHEMBL516566 | 0.76 | CACNA1H (0.46) | PGRCYP2A6ALDH1A1CA12CA2 | |
| SCHEMBL10180619 | 0.72 | TAAR1 (0.42) | CYP2A6ALDH1A1 | |
| SCHEMBL19817412 | 0.72 | MAOB (0.43) | — | |
| SCHEMBL2327140 | 0.72 | CACNA1H (0.49) | PGRCYP2A6ALDH1A1CA12CA2 | |
| SCHEMBL9920452 | 0.72 | PNMT (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261766-A1 | Phenyl-Oxetanyl-Derivatives | NOVARTIS AG (CH) | 2010-10-14 | — | — | US | disclosed |
| EP-2227459-A2 | PHENYL-OXETANYL-DERIVATIVES | Novartis AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009068682-A2 | PHENYL-OXETANYL-DERIVATIVES | NOVARTIS AG (CH) | 2009-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261766-A1 | Phenyl-Oxetanyl-Derivatives | SSB, OAT, OTC | PGR 1483/4885LOXL2 811/4885CYP2A6 349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.