Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 1/20 | 0.38 |
| ▸ | LIPC | P11150 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 12/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.32 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.31 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25325591 | 1.00 | LPL (0.38) | LPLLIPCLIPGMGLLFAAH | |
| SCHEMBL25918910 | 0.89 | LIPG (0.42) | LPLLIPCLIPGMGLLFAAH | |
| SCHEMBL30553208 | 0.85 | MGLL (0.42) | MGLLENPP2ATXN2ADORA2BGLS | |
| SCHEMBL25324678 | 0.85 | MGLL (0.42) | MGLLENPP2ATXN2ADORA2BGLS | |
| SCHEMBL30553286 | 0.83 | ENPP2 (0.37) | MGLLFAAHENPP2 | |
| SCHEMBL25325767 | 0.83 | ENPP2 (0.37) | MGLLFAAHENPP2 | |
| SCHEMBL25324545 | 0.82 | ENPP2 (0.41) | LPLLIPCLIPGMGLLFAAH | |
| SCHEMBL30012148 | 0.81 | MGLL (0.53) | LPLLIPCLIPGMGLLFAAH | |
| SCHEMBL27153936 | 0.81 | MGLL (0.53) | LPLLIPCLIPGMGLLFAAH | |
| SCHEMBL25326458 | 0.81 | ENPP2 (0.42) | MGLLENPP2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469446-A1 | NEW HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2024-12-04 | — | — | EP | claimed |
| WO-2023144160-A1 | NEW HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-03 | — | — | WO | claimed |
| EP-4469446-A1 | NEW HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023144160-A1 | NEW HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-03 | — | — | WO | disclosed |