Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.56 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.43 |
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 7/20 | 0.94 |
| ▸ | CA2 | P00918 | 7/20 | 0.94 |
| ▸ | CA12 | O43570 | 6/20 | 0.94 |
| ▸ | CA7 | P43166 | 6/20 | 0.94 |
| ▸ | CA9 | Q16790 | 6/20 | 0.94 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CA6 | P23280 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | BID | P55957 | 4/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5603402 | 0.97 | CA1 (1.00) | CA1CA2CA12CA7CA9 | |
| SCHEMBL224031 | 0.97 | CA1 (1.00) | CA1CA2CA12CA7CA9 | |
| SCHEMBL8920126 | 0.94 | CA1 (0.94) | CA1CA2CA12CA7CA9 | |
| SCHEMBL18920884 | 0.94 | CA12 (0.94) | CA1CA2CA12CA7CA9 | |
| SCHEMBL18920879 | 0.94 | CA1 (0.94) | CA1CA2CA12CA7CA9 | |
| SCHEMBL8213147 | 0.94 | CA1 (0.94) | CA1CA2CA12CA7CA9 | |
| SCHEMBL8921906 | 0.94 | CA1 (0.94) | CA1CA2CA12CA7CA9 | |
| SCHEMBL27310020 | 0.94 | CA1 (0.94) | CA1CA2CA12CA7CA9 | |
| Hydrochloric Acid SCHEMBL8394452 | 0.94 | CA1 (0.94) | CA1CA2CA12CA7CA9 | |
| Tetramethylammonium Ion SCHEMBL9060253 | 0.87 | CA12 (0.81) | CA1CA2CA12CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116813543-A | Milrinone eutectic solvate | 山东新时代药业有限公司 | 2023-09-29 | — | — | CN | claimed |
| CN-116813543-A | Milrinone eutectic solvate | 山东新时代药业有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-116813543-A | Milrinone eutectic solvate | 山东新时代药业有限公司 | 2023-09-29 | — | — | CN | disclosed |