Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 11/20 | 0.48 |
| ▸ | HTR2A | P28223 | 10/20 | 0.48 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.47 |
| ▸ | APAF1 | O14727 | 2/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258385 | 0.83 | HTR2C (0.50) | HTR2CHTR2ANTSR1APAF1ITGB3 | |
| SCHEMBL15712674 | 0.82 | HTR2C (0.55) | HTR2CHTR2ANTSR1CYP1A2CYP3A4 | |
| SCHEMBL2869168 | 0.77 | KMT2A (0.60) | NTSR1KMOKDM4EALDH1A1POLB | |
| SCHEMBL13139567 | 0.76 | NTSR1 (0.45) | HTR2CHTR2ANTSR1KMOCYP3A4 | |
| SCHEMBL3353214 | 0.74 | LMNA (0.44) | HTR2CHTR2ANTSR1KMOCYP3A4 | |
| SCHEMBL3345985 | 0.73 | PRKCI (0.44) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3354522 | 0.72 | GRIN2B (0.45) | NTSR1CYP2C9 | |
| SCHEMBL3355234 | 0.72 | KDM4E (0.48) | NTSR1CYP3A4CYP2C9KDM4EALDH1A1 | |
| SCHEMBL3354646 | 0.72 | NTSR1 (0.51) | NTSR1CYP3A4CYP2C9KDM4EALDH1A1 | |
| SCHEMBL3061732 | 0.71 | HTR2A (0.43) | HTR2CHTR2ANTSR1APAF1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | BDKRB1, BDKRB2, EDNRB | HTR2C 221/4885HTR2A 85/4885NTSR1 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.