Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 3/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3043132 | 0.97 | METAP2 (0.37) | HSD11B1HSD17B1HSD17B2HRH3BDKRB1 | |
| SCHEMBL3061724 | 0.87 | CACNA2D1 (0.39) | HSD11B1HSD17B1HSD17B2HRH3BDKRB1 | |
| SCHEMBL3053503 | 0.85 | DRD2 (0.38) | HSD11B1HSD17B1HSD17B2BDKRB1 | |
| SCHEMBL3056130 | 0.83 | BDKRB1 (0.51) | BDKRB1ACHECCR3ALDH1A1MAPK1 | |
| SCHEMBL13139531 | 0.81 | HSD17B1 (0.43) | HSD17B1HSD17B2TP53ALDH1A1HSD17B10 | |
| SCHEMBL3053031 | 0.81 | HSD17B1 (0.45) | HSD17B1HSD17B2TP53ALDH1A1HSD17B10 | |
| SCHEMBL3061729 | 0.80 | BDKRB1 (0.51) | BDKRB1ALDH1A1MAPK1HSD17B10 | |
| SCHEMBL3056165 | 0.76 | HSD17B1 (0.47) | HSD17B1HSD17B2TP53ALDH1A1HSD17B10 | |
| SCHEMBL3055517 | 0.73 | BDKRB1 (0.39) | BDKRB1 | |
| SCHEMBL3051446 | 0.73 | S1PR1 (0.44) | HSD17B1HSD17B2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | claimed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | claimed |
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | BDKRB1, BDKRB2, EDNRB | HSD11B1 1289/4885HSD17B1 2880/4885HSD17B2 3507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.