Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 13/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3056130 | 0.97 | BDKRB1 (0.51) | BDKRB1ALDH1A1KMT2ATSHRMAPK1 | |
| SCHEMBL3051543 | 0.90 | BDKRB1 (0.52) | BDKRB1KMT2AMEN1 | |
| SCHEMBL3055551 | 0.84 | BDKRB1 (0.41) | BDKRB1L3MBTL1 | |
| SCHEMBL3043132 | 0.83 | METAP2 (0.37) | BDKRB1ALDH1A1MAPK1HSD17B10 | |
| SCHEMBL3060341 | 0.83 | BDKRB1 (0.53) | BDKRB1 | |
| SCHEMBL3052564 | 0.81 | OPRD1 (0.38) | BDKRB1HSD17B10L3MBTL1 | |
| SCHEMBL3065418 | 0.81 | GAA (0.40) | ALDH1A1KMT2ATSHRHSD17B10MEN1 | |
| SCHEMBL13139533 | 0.81 | GAA (0.40) | ALDH1A1KMT2ATSHRHSD17B10MEN1 | |
| SCHEMBL3046916 | 0.81 | BDKRB1 (0.39) | BDKRB1MAPK1HSD17B10L3MBTL1 | |
| SCHEMBL3056953 | 0.80 | HSD11B1 (0.36) | BDKRB1ALDH1A1MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | claimed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | claimed |
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | BDKRB1, BDKRB2, EDNRB | BDKRB1 1/4885ALDH1A1 1551/4885KMT2A 2512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.