Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.32 |
| ▸ | HTR6 | P50406 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3062814 | 0.73 | HTR6 (0.46) | OPRD1OPRK1BDKRB1HTR6 | |
| SCHEMBL3053112 | 0.73 | ALDH1A1 (0.46) | HTR6 | |
| SCHEMBL13139524 | 0.70 | HTR6 (0.46) | HTR6 | |
| SCHEMBL3053633 | 0.70 | KMO (0.46) | HTR6 | |
| SCHEMBL3057526 | 0.69 | ALDH1A1 (0.43) | HTR6 | |
| SCHEMBL3052860 | 0.68 | HTR6 (0.40) | OPRD1OPRK1BDKRB1HTR6 | |
| SCHEMBL13139522 | 0.68 | ALDH1A1 (0.42) | HTR6 | |
| SCHEMBL3042694 | 0.68 | CYP2D6 (0.45) | — | |
| SCHEMBL3052540 | 0.67 | HTR6 (0.35) | OPRD1OPRK1BDKRB1HTR6 | |
| SCHEMBL3051549 | 0.66 | OPRD1 (0.36) | OPRD1OPRK1BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | claimed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | claimed |
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | BDKRB1, BDKRB2, EDNRB | OPRD1 33/4885OPRK1 16/4885BDKRB1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.