Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | NOS1 | P29475 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ACLY | P53396 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27659736 | 0.98 | MAPK1 (0.54) | MAPK1NOS1MAPTPOLBMAOB | |
| SCHEMBL31475220 | 0.86 | NOS1 (0.51) | MAPK1NOS1MAPTMEN1KMT2A | |
| SCHEMBL4654871 | 0.86 | NOS1 (0.51) | MAPK1NOS1MAPTMEN1KMT2A | |
| SCHEMBL6298004 | 0.82 | NOS1 (0.51) | MAPK1NOS1MAPTPOLBMAOB | |
| SCHEMBL29509879 | 0.82 | NOS1 (0.55) | MAPK1NOS1MAPTPOLBMAOB | |
| SCHEMBL5220947 | 0.82 | KDR (0.57) | MAPK1NOS1MAPTPOLBMAOB | |
| SCHEMBL692845 | 0.82 | NOS1 (0.55) | MAPK1NOS1MAPTPOLBMAOB | |
| SCHEMBL31647068 | 0.82 | KDR (0.57) | MAPK1NOS1MAPTPOLBMAOB | |
| SCHEMBL10179696 | 0.82 | TMEM97 (0.52) | MAPK1NOS1MAPTPOLBMAOB | |
| SCHEMBL19639914 | 0.78 | ROCK2 (0.50) | MAPK1NOS1MAPTPOLBMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114773266-B | Improved synthesis method of montelukast sodium | 牡丹江恒远药业股份有限公司 | 2022-12-27 | — | — | CN | claimed |
| CN-114773266-A | Improved synthesis method of montelukast sodium | 牡丹江恒远药业股份有限公司 | 2022-07-22 | — | — | CN | claimed |
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | ROCHE PALO ALTO LLC | 2010-10-21 | — | — | US | claimed |
| CN-114773266-B | Improved synthesis method of montelukast sodium | 牡丹江恒远药业股份有限公司 | 2022-12-27 | — | — | CN | disclosed |
| CN-114773266-A | Improved synthesis method of montelukast sodium | 牡丹江恒远药业股份有限公司 | 2022-07-22 | — | — | CN | disclosed |
| US-10752617-B2 | Indazole sulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (ROR gamma (T)) | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2020-08-25 | — | — | US | disclosed |
| US-20190202819-A1 | INDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2019-07-04 | — | — | US | disclosed |
| US-10246440-B2 | Indazole sulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (ROR γ (T)) | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2019-04-02 | — | — | US | disclosed |
| US-20170342062-A1 | INDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2017-11-30 | — | — | US | disclosed |
| EP-2610247-B1 | Arylsulfonyl pyrazoline carboxamidine derivatives as 5-HT6 antagonists | ABBVIE BAHAMAS LTD (BS) | 2016-05-25 | — | — | EP | disclosed |
| EP-2265589-B1 | ARYLSULFONYL PYRAZOLINE CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS | ABBVIE BAHAMAS LTD (BS) | 2016-01-27 | — | — | EP | disclosed |
| EP-0696759-B1 | Method for processing a silver halide photographic light-sensitive material | KONISHIROKU PHOTO IND (JP) | 2000-03-29 | — | — | EP | disclosed |
| US-5707788-A | REDUCING DEVELOPER WASTE WHILE MAINTAINING IMAGE QUALITY, BLACK AND WHITE | KONICA CORPORATION (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0554000-B1 | A black-and-white silver halide photographic light-sensitive material and a method for processing the same | KONISHIROKU PHOTO IND (JP) | 1997-03-19 | — | — | EP | disclosed |
| EP-0696759-A2 | Method for processing a silver halide photographic light-sensitive material | KONICA CORPORATION (JP) | 1996-02-14 | — | — | EP | disclosed |
| US-5376509-A | Comprising cyclodextrin compounds and devloper; storage stable | KONICA CORPORATION (JP) | 1994-12-27 | — | — | US | disclosed |
| US-5352563-A | At least one of emulsion and protective layers contains a cyclodextrin compound; hydrazine derivative or tetrazolium salt in emulsion layer | KONICA CORPORATION (JP) | 1994-10-04 | — | — | US | disclosed |
| EP-0554000-A1 | A black-and-white silver halide photographic light-sensitive material and a method for processing the same | KONICA CORPORATION (JP) | 1993-08-04 | — | — | EP | disclosed |
| EP-0545645-A1 | Solid processing chemicals for light-sensitive halide photographic material | KONICA CORPORATION (JP) | 1993-06-09 | — | — | EP | disclosed |
| EP-0358165-A2 | Method of developing a silver halide photographic material | KONICA CORPORATION (JP) | 1990-03-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10246440-B2 | Indazole sulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (ROR γ (T)) | RORA, RORB, RORC | MAPK1 3487/4885NOS1 2823/4885MAPT 673/4885 |
| US-20170342062-A1 | INDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | RORA, RORB, RORC | MAPK1 3509/4885NOS1 2915/4885MAPT 664/4885 |
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | SYK, ZAP70, TYK2 | MAPK1 386/4885NOS1 1181/4885MAPT 3747/4885 |
| US-20190202819-A1 | INDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | RORA, RORB, RORC | MAPK1 3509/4885NOS1 2915/4885MAPT 664/4885 |
| US-10752617-B2 | Indazole sulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (ROR gamma (T)) | RORA, RORB, RORC | MAPK1 3509/4885NOS1 2915/4885MAPT 664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.