Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 7/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29084839 | 1.00 | DRD2 (0.41) | DRD2DRD1DRD5NR4A2KIF11 | |
| SCHEMBL31070497 | 0.89 | NR4A2 (0.42) | NR4A2HTR6ICMTCNR2IKBKB | |
| SCHEMBL30593227 | 0.88 | ECE1 (0.44) | DRD2DRD1DRD5KIF11HSD11B1 | |
| SCHEMBL30593308 | 0.88 | KIF11 (0.46) | KIF11HSD11B1KDM4ELMNAMAPT | |
| SCHEMBL31083752 | 0.87 | KIF11 (0.49) | NR4A2KIF11HTR6ICMTHSD11B1 | |
| SCHEMBL30593317 | 0.87 | HSD11B1 (0.43) | ICMTHSD11B1 | |
| SCHEMBL31083748 | 0.87 | KIF11 (0.48) | KIF11HSD11B1MAPT | |
| SCHEMBL31083802 | 0.87 | ECE1 (0.38) | KIF11HTR6HSD11B1 | |
| SCHEMBL31083737 | 0.86 | GRM4 (0.41) | DRD2DRD1DRD5KIF11HSD11B1 | |
| SCHEMBL30593291 | 0.86 | KIF11 (0.52) | DRD2DRD1DRD5KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118742543-A | Dihydro isoquinoline compound and medical application thereof | 中国科学院上海药物研究所 | 2024-10-01 | — | — | CN | disclosed |
| CN-116789641-A | Dihydro isoquinoline compound and medical application thereof | 中国科学院上海药物研究所 | 2023-09-22 | — | — | CN | disclosed |