Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 14/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.41 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709922 | 0.88 | PIK3CA (0.46) | PIK3CAPRKAA2STAT3 | |
| Bromide SCHEMBL3065325 | 0.88 | PIK3CA (0.46) | PIK3CAPRKAA2STAT3 | |
| Bromide SCHEMBL3053365 | 0.86 | PRKAA2 (0.47) | PIK3CAPRKAA2STAT3SMN1; SMN2 | |
| SCHEMBL3052158 | 0.84 | SMN1; SMN2 (0.46) | PIK3CAPRKAA2STAT3KDM4ELMNA | |
| SCHEMBL3053251 | 0.83 | LGALS8 (0.42) | LGALS8LGALS3MEN1KMT2A | |
| SCHEMBL3055758 | 0.82 | LGALS8 (0.40) | LMNASMN1; SMN2ALDH1A1LGALS8LGALS3 | |
| Maleic Acid SCHEMBL3061327 | 0.82 | PIK3CA (0.41) | PIK3CAPRKAA2STAT3KDM4ELMNA | |
| Fumaric Acid SCHEMBL3061331 | 0.82 | PIK3CA (0.41) | PIK3CAPRKAA2STAT3KDM4ELMNA | |
| Bromide SCHEMBL3062140 | 0.82 | PTGS2 (0.52) | PIK3CAPRKAA2STAT3 | |
| Bromide SCHEMBL3068012 | 0.81 | PRKAA2 (0.46) | PIK3CAPRKAA2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8551999-B2 | Heterocyclic compound and pharmaceutical composition thereof | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-10-08 | — | — | US | disclosed |
| US-20100261720-A1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261720-A1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | COL1A1, COL2A1, COL14A1 | PIK3CA 3582/4885PRKAA2 4297/4885STAT3 1499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.